Dhara Patel assists the firm in biotechnology patent prosecution with a particular focus in molecular biology, cell biology, lab automation and high throughput screening (HTS), biochemistry, immunology, biophysics, and drug discovery.

Prior to joining Wolf Greenfield, Dhara was a tenure-track Instructor at the Washington University School of Medicine in St. Louis, where she identified and evaluated small molecules for the development of broad-spectrum antiviral therapeutics, studied novel STAT1-interacting partners as effectors of antiviral immunity and developed fluorescence polarization kinase activity assay for lead optimization of p38δ-MAPK inhibitors as anti-mucus therapeutics.

Dhara has experience in multiple disease areas including Alzheimer’s disease, corneal dystrophies and viral infections. She has served as reviewer for the Biotechnology, Biochemical and Biomass Engineering Program at NSF and the American Chemical Society Symposium Series, and serves as an ad-hoc reviewer for several journals including the J. Biomol. Screening, Am. J. Respir. Crit. Care Med., Am. J. Respir. Cell Mol. Biol, and International Journal of Biomacromolecules.
  • Association for Women in Science (AWIS) - Massachusetts Chapter (Scholarship and Sponsorship committees)
  • Society for Lab Automation and Screening
  • Phi Kappa Phi Honor Society
  • Tau Beta Pi Engineering Honor Society
  • American Chemical Society
  • Fellowship in Respiratory Research (Parker B Francis Foundation)
  • Building Interdisciplinary Careers in Women’s Health (BIRCWH) Fellowship (NIH K12) Asthma & Allergic Disease Coop. Res. Centers (AADCRC) Early Investigator Award (NIH/NIAID)
  • Principles in Pulmonary Research trainee (NIH/NHLBI T32 training award)
  • Research in the Vision Sciences trainee (NIH/NEI T32 training award)
  • Tony B. Academic Travel Awards, SLAS (Society for Lab Automation and Screening)


Scientific Publications

Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochimica et Biophysica Acta. 2016;pii: S0304-4165(16)30228-8.

Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Ommatage NS, Brett TJ, Holtzman MJ. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Nat Immunol 2015; 16(12): 1215-1227.

Patel DA, You Y, Huang G, Byers DE, Kim HK, Agapov E, Moore ML, Peebles RS, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. J. Allergy & Clin. Immnol. 2014; 134(6): 1402-­‐1412.

Patel DA*, Patel AC, Nolan WC, Huang G, Romero AG, Charlton N, Agapov E, Zhang Y, Holtzman MJ*. High-­‐Throughput screening normalized to biological response: application to antiviral drug discovery. J. Biomol. Screen. Phenotypic Drug Discovery Special Issue. 2013; 19(1):119-­‐130. *Co-­‐corresponding authors

Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ. Signaling from CLCA1 to MAPK13 provides a new pathway to block IL-­‐13-­‐induced airway mucus production. J Clin Invest. 2012;122:4555-­‐68. (patent application from this work published)

Patel DA, Patel AC, Nolan WC, Zhang Y, Holtzman MJ. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-­‐generation antiviral drug discovery. PloS One. 2012;7(5):e36594.

Patel DA, Harocopos GJ, Chang SH, Vora SC, Lubniewski AJ, Huang AJ. Novel CHST6 gene mutations in 2 unrelated cases of macular corneal dystrophy. Cornea. 2011;30(6):664-­‐9.

Patel DA, Chang SH, Harocopos GJ, Vora SC, Thang DH, Huang AJ. Granular and lattice deposits in corneal dystrophy caused by R124C mutation of TGFBIp. Cornea. 2010;29(11):1215-­‐22.

Cowan CB, Patel DA, Good TA. Exploring the mechanism of beta-­‐amyloid toxicity attenuation by multivalent sialic acid polymers through the use of mathematical models. J Theor Biol. 2009;258(2):189-­‐97.

Qi W, Zhang A, Patel D, Lee S, Harrington JL, Zhao L, Schaefer D, Good TA, Fernandez EJ. Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-­‐40) fibrillogenesis. Biotechnol Bioeng. 2008;100(6):1214-­‐27.

Patel DA, Henry JE, Good TA. Attenuation of beta-­‐amyloid-­‐induced toxicity by sialic-­‐acid-­‐conjugated dendrimers: role of sialic acid attachment. Brain Res. 2007;1161:95-­‐105.

Patel D, Good T. A rapid method to measure beta-­‐amyloid induced neurotoxicity in vitro. J Neurosci Methods. 2007;161(1):1-­‐10


Expand All

Dhara Patel assists the firm in biotechnology patent prosecution with a particular focus in molecular biology, cell biology, lab automation and high throughput screening (HTS), biochemistry, immunology, biophysics, and drug discovery.

Prior to joining Wolf Greenfield, Dhara was a tenure-track Instructor at the Washington University School of Medicine in St. Louis, where she identified and evaluated small molecules for the development of broad-spectrum antiviral therapeutics, studied novel STAT1-interacting partners as effectors of antiviral immunity and developed fluorescence polarization kinase activity assay for lead optimization of p38δ-MAPK inhibitors as anti-mucus therapeutics.

Dhara has experience in multiple disease areas including Alzheimer’s disease, corneal dystrophies and viral infections. She has served as reviewer for the Biotechnology, Biochemical and Biomass Engineering Program at NSF and the American Chemical Society Symposium Series, and serves as an ad-hoc reviewer for several journals including the J. Biomol. Screening, Am. J. Respir. Crit. Care Med., Am. J. Respir. Cell Mol. Biol, and International Journal of Biomacromolecules.
  • Association for Women in Science (AWIS) - Massachusetts Chapter (Scholarship and Sponsorship committees)
  • Society for Lab Automation and Screening
  • Phi Kappa Phi Honor Society
  • Tau Beta Pi Engineering Honor Society
  • American Chemical Society
  • Fellowship in Respiratory Research (Parker B Francis Foundation)
  • Building Interdisciplinary Careers in Women’s Health (BIRCWH) Fellowship (NIH K12) Asthma & Allergic Disease Coop. Res. Centers (AADCRC) Early Investigator Award (NIH/NIAID)
  • Principles in Pulmonary Research trainee (NIH/NHLBI T32 training award)
  • Research in the Vision Sciences trainee (NIH/NEI T32 training award)
  • Tony B. Academic Travel Awards, SLAS (Society for Lab Automation and Screening)

Scientific Publications

Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochimica et Biophysica Acta. 2016;pii: S0304-4165(16)30228-8.

Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Ommatage NS, Brett TJ, Holtzman MJ. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Nat Immunol 2015; 16(12): 1215-1227.

Patel DA, You Y, Huang G, Byers DE, Kim HK, Agapov E, Moore ML, Peebles RS, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. J. Allergy & Clin. Immnol. 2014; 134(6): 1402-­‐1412.

Patel DA*, Patel AC, Nolan WC, Huang G, Romero AG, Charlton N, Agapov E, Zhang Y, Holtzman MJ*. High-­‐Throughput screening normalized to biological response: application to antiviral drug discovery. J. Biomol. Screen. Phenotypic Drug Discovery Special Issue. 2013; 19(1):119-­‐130. *Co-­‐corresponding authors

Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ. Signaling from CLCA1 to MAPK13 provides a new pathway to block IL-­‐13-­‐induced airway mucus production. J Clin Invest. 2012;122:4555-­‐68. (patent application from this work published)

Patel DA, Patel AC, Nolan WC, Zhang Y, Holtzman MJ. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-­‐generation antiviral drug discovery. PloS One. 2012;7(5):e36594.

Patel DA, Harocopos GJ, Chang SH, Vora SC, Lubniewski AJ, Huang AJ. Novel CHST6 gene mutations in 2 unrelated cases of macular corneal dystrophy. Cornea. 2011;30(6):664-­‐9.

Patel DA, Chang SH, Harocopos GJ, Vora SC, Thang DH, Huang AJ. Granular and lattice deposits in corneal dystrophy caused by R124C mutation of TGFBIp. Cornea. 2010;29(11):1215-­‐22.

Cowan CB, Patel DA, Good TA. Exploring the mechanism of beta-­‐amyloid toxicity attenuation by multivalent sialic acid polymers through the use of mathematical models. J Theor Biol. 2009;258(2):189-­‐97.

Qi W, Zhang A, Patel D, Lee S, Harrington JL, Zhao L, Schaefer D, Good TA, Fernandez EJ. Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-­‐40) fibrillogenesis. Biotechnol Bioeng. 2008;100(6):1214-­‐27.

Patel DA, Henry JE, Good TA. Attenuation of beta-­‐amyloid-­‐induced toxicity by sialic-­‐acid-­‐conjugated dendrimers: role of sialic acid attachment. Brain Res. 2007;1161:95-­‐105.

Patel D, Good T. A rapid method to measure beta-­‐amyloid induced neurotoxicity in vitro. J Neurosci Methods. 2007;161(1):1-­‐10