Gabe McCool has over 17 years of experience advising clients in the life science industry on intellectual property matters, particularly in the areas of patent preparation, prosecution, and strategic counseling. He has advised biopharmaceutical, biomedical device, pharmaceutical, contract manufacturing, and molecular diagnostic companies of all sizes and stages of growth, ranging from startup companies through global corporations. Gabe also has extensive experience counseling universities and research institutes on a range of patent matters. In addition, he has significant in-house experience at a global biopharmaceutical corporation as a seconded patent attorney where he developed patent portfolios covering FDA-approved biologics and pharmaceutical products.

Gabe's experience spans a wide range of biotechnology areas, including therapeutic antibodies and proteins, pharmaceuticals, stem cells, genome-editing technology, bioprocessing, gene therapy, medical diagnostics, vaccines, nucleic acid-based therapies, and biomedical devices.

In addition, he has substantial experience in conducting patentability studies, freedom-to-operate analyses, and due diligence, as well as providing legal opinions addressing patentability, clearance, and validity inquiries. He has also has experience with post-grant proceedings and interferences before the USPTO, as well as opposition proceedings before the European Patent Office. Gabe has also supported various litigations involving generic drug patent disputes arising under the Hatch-Waxman Act and has provided counseling on biosimilars and the Biologics Price Competition and Innovation Act.

Gabe’s doctoral research focused on understanding the genetic and biochemical basis of polyhydroxyalkanoate synthesis in bacteria and their application as bioplastics.

  • American Bar Association
  • New York Intellectual Property Association
  • Boston Patent Law Association
  • Pro Bono Volunteer – Connecticut Veterans Legal Center
  • Pro Bono Volunteer – Law Rocks Inc. Charity
  • Advisory Board, College of Natural Sciences, University of Massachusetts, Amherst (2011-2015) 
  • Co-Chair, Intellectual Property Committee, Fairfield County Bar Association (2012-2014)

  • Founder, UMass Amherst Life Science Alumni Network, University of Massachusetts, Amherst (2013-present)
  • Recipient, American Society for Microbiology Outstanding Graduate Research Award (2000)


  • Gabriel J. McCool, In re Kubin: Is “obvious to try” the new standard for biotechnology inventions?, Edwards Wildman IP Bulletin Summer/Fall Issue, 2009, at 1, available at http://www.edwardswildman.com/newsstand/detail.aspx?news=1740.
  • Gabriel J. McCool et al., U.S. Patent No. 6,835,820, issued December 28, 2004, entitled Polyhydroxyalkanoate biosynthesis associated proteins and coding region in Bacillus megaterium.
  • Gabriel J. McCool and Maura C. Cannon, PhaC and PhaR are required for polyhydroxyalkanoic acid synthesis in Bacillus megaterium, Journal of Bacteriology, Vol. 183, 2001, at 4235.
  • Gabriel J. McCool and Maura C. Cannon, Polyhydroxyalkanoate inclusion-body associated proteins and coding region in Bacillus megaterium, Journal of Bacteriology, Vol. 181, 1999, at 85.
  • Gabriel J. McCool, Potential Impact of Recent Supreme Court Decision on Access to Attorney’s Fees, Inside – a publication of the Corporate Counsel Section of the New York State Bar Association; Fall 2014. 
  • Gabriel J. McCool and Ralph A. Loren, PTAB Use Of Redundancy May Have Unfair Estoppel Effect, IP Law 360, March 21, 2014.

  • Faculty, Patent Fundamentals Bootcamp 2020: An Introduction to Patent Drafting, Prosecution, and Litigation NY. Practicing Law Institute, New York, NY
  • Presenter, Introduction to Intellectual Property, Presentation at the Broad Institute, June 6, 2019
  • Presenter, The Mechanics of Enforcing IP Rights for Early-Stage Biotech Startups, Presentation at Alexandria LaunchLabs®, New York City, May 21, 2019
  • Presenter, IP Strategies for Life Science Startups, Presentation at Alexandria LaunchLabs®, New York City, January 24, 2019
  • Presenter, Life Sciences Start-ups: Insights for Success, UMass Amherst Life Science Alumni Network, October 30, 2019, Boston, MA
  • Presenter, IP Strategies – Managing Risks and Opportunities, Presentation at Alexandria LaunchLabs®, New York City, October 17, 2018
  • Moderator, IP Issues in Rare Diseases: Addressing the Unmet Need, AUTM Regional Meeting, September 13, 2018, Baltimore, MD, Satinder Rawat, Ph.D. and Debra K. Bowes
  • Presenter, Hot-Button Legal Challenges in Bringing Biosimilars and Interchangeables to Market, Society for Industrial Microbiology and Biotechnology, August 13, 2018, Chicago, IL
  • Faculty, Patent Fundamentals Bootcamp 2019: An Introduction to Patent Drafting, Prosecution, and Litigation NY. Practicing Law Institute, New York, NY
  • Organized and Hosted, Biotech Opportunities Through Industry and Academic Collaborations, UMass Club, Boston, Massachusetts, September 21, 2016, in connection with the UMass Amherst Life Science Alumni Network.
  • Organized and Hosted, The Science of Brewing, Harpoon Brewery, Boston, Massachusetts, March 23, 2016, in connection with the UMass Amherst Life Science Alumni Network.
  • Organized and Hosted, The Story of GeckSkin® HiTech Adhesive, UMass Club, Boston, Massachusetts, November 5, 2015, in connection with the UMass Amherst Life Science Alumni Network.
  • Presented, Gabriel J. McCool, Practical Look at Subject Matter Eligibility Under 35 U.S.C. 101, Presentation given at MIT’s Technology Licensing Office, December 3, 2015.
  • Organized and Hosted, Leading the Way: UMass and Life Sciences Collaborations, UMass Club, Boston, Massachusetts, June 30, 2015, in connection with the UMass Amherst Life Science Alumni Network.
  • Organized and Hosted, University Collaborations with Genzyme Corporation, UMass Club, Boston, Massachusetts, June 12, 2014, in connection with the UMass Amherst Life Science Alumni Network.
  • Presented, Gabriel J. McCool and Bryan Zerhusen, Presenters, IP Basics for Entrepreneurs and Tech Startups: Trademarks and Copyrights, Podcast Presentation, Connecticut Innovations Resource Library (www.ctinnovations.com), May 1, 2014.
  • Presented, Gabriel J. McCool and Bryan Zerhusen, Presenters, IP Basics for Entrepreneurs and Tech Startups: Patents and Trade Secrets, Podcast Presentation, Connecticut Innovations Resource Library (www.ctinnovations.com), March 14, 2014.
  • Presented, Gabriel J. McCool, Lecturer, IP Law 101 for Entrepreneurs and Tech Startups, November 20, 2013, Part of the Innovation Ed Program at the Stamford Innovation Center, Stamford Connecticut.
  • Moderater, Gabriel J. McCool, Moderator, Navigating Business, Investment, and Legal Challenges Facing Entrepreneurs: Laying the Foundation for a Successful Startup, Panel discussion for the Fairfield County Bar Association, June 13, 2013, Stamford Innovation Center, Stamford Connecticut.
  • Presented, Gabriel J. McCool, Presenter, McCarter & English Intellectual Property Practice Group Presentation: Retractable Technologies, Inc. v. Becton, Dickinson (November 2012).
  • Presented, Brian M. Gaff, Ralph A. Loren, and Gabriel J. McCool, Computing and the Law: Intellectual Property: Part I, Computer, January 2012, at 14.
  • Presented, Gabriel J. McCool, Panelist, Science Entrepreneurs Forum at the University of Massachusetts, Amherst, (November 3, 2011).

Gabe is a co-inventor on US Patent No. 6,835,820, which relates to his doctoral research. Gabe has also co-authored numerous scientific and legal publications and regularly moderates and/or presents on IP-related topics.


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Gabe McCool has over 17 years of experience advising clients in the life science industry on intellectual property matters, particularly in the areas of patent preparation, prosecution, and strategic counseling. He has advised biopharmaceutical, biomedical device, pharmaceutical, contract manufacturing, and molecular diagnostic companies of all sizes and stages of growth, ranging from startup companies through global corporations. Gabe also has extensive experience counseling universities and research institutes on a range of patent matters. In addition, he has significant in-house experience at a global biopharmaceutical corporation as a seconded patent attorney where he developed patent portfolios covering FDA-approved biologics and pharmaceutical products.

Gabe's experience spans a wide range of biotechnology areas, including therapeutic antibodies and proteins, pharmaceuticals, stem cells, genome-editing technology, bioprocessing, gene therapy, medical diagnostics, vaccines, nucleic acid-based therapies, and biomedical devices.

In addition, he has substantial experience in conducting patentability studies, freedom-to-operate analyses, and due diligence, as well as providing legal opinions addressing patentability, clearance, and validity inquiries. He has also has experience with post-grant proceedings and interferences before the USPTO, as well as opposition proceedings before the European Patent Office. Gabe has also supported various litigations involving generic drug patent disputes arising under the Hatch-Waxman Act and has provided counseling on biosimilars and the Biologics Price Competition and Innovation Act.

Gabe’s doctoral research focused on understanding the genetic and biochemical basis of polyhydroxyalkanoate synthesis in bacteria and their application as bioplastics.

  • American Bar Association
  • New York Intellectual Property Association
  • Boston Patent Law Association
  • Pro Bono Volunteer – Connecticut Veterans Legal Center
  • Pro Bono Volunteer – Law Rocks Inc. Charity
  • Advisory Board, College of Natural Sciences, University of Massachusetts, Amherst (2011-2015) 
  • Co-Chair, Intellectual Property Committee, Fairfield County Bar Association (2012-2014)

  • Founder, UMass Amherst Life Science Alumni Network, University of Massachusetts, Amherst (2013-present)
  • Recipient, American Society for Microbiology Outstanding Graduate Research Award (2000)
  • Gabriel J. McCool, In re Kubin: Is “obvious to try” the new standard for biotechnology inventions?, Edwards Wildman IP Bulletin Summer/Fall Issue, 2009, at 1, available at http://www.edwardswildman.com/newsstand/detail.aspx?news=1740.
  • Gabriel J. McCool et al., U.S. Patent No. 6,835,820, issued December 28, 2004, entitled Polyhydroxyalkanoate biosynthesis associated proteins and coding region in Bacillus megaterium.
  • Gabriel J. McCool and Maura C. Cannon, PhaC and PhaR are required for polyhydroxyalkanoic acid synthesis in Bacillus megaterium, Journal of Bacteriology, Vol. 183, 2001, at 4235.
  • Gabriel J. McCool and Maura C. Cannon, Polyhydroxyalkanoate inclusion-body associated proteins and coding region in Bacillus megaterium, Journal of Bacteriology, Vol. 181, 1999, at 85.
  • Gabriel J. McCool, Potential Impact of Recent Supreme Court Decision on Access to Attorney’s Fees, Inside – a publication of the Corporate Counsel Section of the New York State Bar Association; Fall 2014. 
  • Gabriel J. McCool and Ralph A. Loren, PTAB Use Of Redundancy May Have Unfair Estoppel Effect, IP Law 360, March 21, 2014.

  • Faculty, Patent Fundamentals Bootcamp 2020: An Introduction to Patent Drafting, Prosecution, and Litigation NY. Practicing Law Institute, New York, NY
  • Presenter, Introduction to Intellectual Property, Presentation at the Broad Institute, June 6, 2019
  • Presenter, The Mechanics of Enforcing IP Rights for Early-Stage Biotech Startups, Presentation at Alexandria LaunchLabs®, New York City, May 21, 2019
  • Presenter, IP Strategies for Life Science Startups, Presentation at Alexandria LaunchLabs®, New York City, January 24, 2019
  • Presenter, Life Sciences Start-ups: Insights for Success, UMass Amherst Life Science Alumni Network, October 30, 2019, Boston, MA
  • Presenter, IP Strategies – Managing Risks and Opportunities, Presentation at Alexandria LaunchLabs®, New York City, October 17, 2018
  • Moderator, IP Issues in Rare Diseases: Addressing the Unmet Need, AUTM Regional Meeting, September 13, 2018, Baltimore, MD, Satinder Rawat, Ph.D. and Debra K. Bowes
  • Presenter, Hot-Button Legal Challenges in Bringing Biosimilars and Interchangeables to Market, Society for Industrial Microbiology and Biotechnology, August 13, 2018, Chicago, IL
  • Faculty, Patent Fundamentals Bootcamp 2019: An Introduction to Patent Drafting, Prosecution, and Litigation NY. Practicing Law Institute, New York, NY
  • Organized and Hosted, Biotech Opportunities Through Industry and Academic Collaborations, UMass Club, Boston, Massachusetts, September 21, 2016, in connection with the UMass Amherst Life Science Alumni Network.
  • Organized and Hosted, The Science of Brewing, Harpoon Brewery, Boston, Massachusetts, March 23, 2016, in connection with the UMass Amherst Life Science Alumni Network.
  • Organized and Hosted, The Story of GeckSkin® HiTech Adhesive, UMass Club, Boston, Massachusetts, November 5, 2015, in connection with the UMass Amherst Life Science Alumni Network.
  • Presented, Gabriel J. McCool, Practical Look at Subject Matter Eligibility Under 35 U.S.C. 101, Presentation given at MIT’s Technology Licensing Office, December 3, 2015.
  • Organized and Hosted, Leading the Way: UMass and Life Sciences Collaborations, UMass Club, Boston, Massachusetts, June 30, 2015, in connection with the UMass Amherst Life Science Alumni Network.
  • Organized and Hosted, University Collaborations with Genzyme Corporation, UMass Club, Boston, Massachusetts, June 12, 2014, in connection with the UMass Amherst Life Science Alumni Network.
  • Presented, Gabriel J. McCool and Bryan Zerhusen, Presenters, IP Basics for Entrepreneurs and Tech Startups: Trademarks and Copyrights, Podcast Presentation, Connecticut Innovations Resource Library (www.ctinnovations.com), May 1, 2014.
  • Presented, Gabriel J. McCool and Bryan Zerhusen, Presenters, IP Basics for Entrepreneurs and Tech Startups: Patents and Trade Secrets, Podcast Presentation, Connecticut Innovations Resource Library (www.ctinnovations.com), March 14, 2014.
  • Presented, Gabriel J. McCool, Lecturer, IP Law 101 for Entrepreneurs and Tech Startups, November 20, 2013, Part of the Innovation Ed Program at the Stamford Innovation Center, Stamford Connecticut.
  • Moderater, Gabriel J. McCool, Moderator, Navigating Business, Investment, and Legal Challenges Facing Entrepreneurs: Laying the Foundation for a Successful Startup, Panel discussion for the Fairfield County Bar Association, June 13, 2013, Stamford Innovation Center, Stamford Connecticut.
  • Presented, Gabriel J. McCool, Presenter, McCarter & English Intellectual Property Practice Group Presentation: Retractable Technologies, Inc. v. Becton, Dickinson (November 2012).
  • Presented, Brian M. Gaff, Ralph A. Loren, and Gabriel J. McCool, Computing and the Law: Intellectual Property: Part I, Computer, January 2012, at 14.
  • Presented, Gabriel J. McCool, Panelist, Science Entrepreneurs Forum at the University of Massachusetts, Amherst, (November 3, 2011).

Gabe is a co-inventor on US Patent No. 6,835,820, which relates to his doctoral research. Gabe has also co-authored numerous scientific and legal publications and regularly moderates and/or presents on IP-related topics.