Chelsea E. Witte-Garcia

Chelsea E. Witte-Garcia, PhD

Counsel | Biotechnology
617.646.8477 LinkedIn Profile


  • BS, Medical Microbiology and Immunology; Spanish, University of Wisconsin
  • PhD, Microbiology, University of California at Berkeley
  • JD, Suffolk University Law School

Key Technologies

  • Infectious Disease Therapeutics
  • Vaccine Development
  • Antibody Technologies
  • Metabolic Engineering
  • Cellular and Gene Therapies
  • Microbiology

Practice Groups

Admitted to Practice

  • Massachusetts
  • US Patent and Trademark Office


  • Boston


Chelsea Witte-Garcia focuses her practice on patent prosecution and counseling across the full spectrum of biotechnology. In particular, Chelsea has extensive experience in the areas of microbiology, immunology, infectious disease therapeutics, vaccine development, antibody technologies, metabolic engineering, gene editing, and nucleic acid sequencing technologies. 

Chelsea counsels clients in US and foreign patent prosecution, working to develop IP portfolio strategies, including competitor analyses, freedom-to-operate, IP due diligence, patentability, trade secrets, and IP opinions.  

Chelsea represents clients from across the world, including individual inventors, small and early stage biotech companies up to large multi-national pharmaceutical corporations. She has a proven track record of building client relationships and is able to function as an extension of her clients’ business to align their IP strategy with their business goals.  

Prior to joining Wolf Greenfield, Chelsea was a postdoctoral research fellow in the Molecular and Microbiology department at Tufts Medical Center. Chelsea’s doctoral work at the University of California, Berkeley focused on understanding how mammalian cells recognize infection with intracellular pathogens, and particularly how cytosolic signaling pathways are stimulated by pathogens and the immunological consequences. Also in this work, Chelsea used molecular and biochemical techniques to understand bacterial small molecule signaling pathways important for bacterial growth, survival, and pathogenesis. 


  • Leadership Council on Legal Diversity Pathfinder (2021)
  • Active participant in Women in Bio


Chelsea is recognized on the Best Lawyers: Ones to Watch list by The Best Lawyers in America®. Chelsea has also been repeatedly named to the list of Massachusetts Rising Stars by Super Lawyers.

Chelsea has received a number of research awards and fellowships for her doctoral and postdoctoral work.


Scientific Publications

  • Witte CE, Whiteley AT, Burke TP, Sauer JD, Portnoy DA, Woodward JJ. (2013) Cyclic diAMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. MBio. 4(3):e00282-13.
  • Witte CE, Archer KA, Rae CS, Sauer JD, Woodward JJ, Portnoy DA. (2012) Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cellmediated immunity. Adv Immunol. 113:135-56.
  • Sauer JD, Witte CE, Zemansky J, Hanson B, Lauer P, Portnoy DA. (2010) Listeria monocytogenes triggers AIM2mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host Microbe. 7(5):412-9.
  • Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE. (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol. (10):1171-8.

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