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There, that wasn’t so bad, was it? Thank you for your interest in Wolf Greenfield.
Pardon the interruption, but we are lawyers after all, so we need to make sure you understand that sending an email does not establish an attorney-client relationship. Also, you need to know the information in your email will not be considered privileged or confidential unless, of course, we already represent you or have agreed to receive limited confidential material from you as a prospective client.
If you are a client, do not send time-sensitive patent filing instructions just to this email recipient. Also send to filinginstructions@wolfgreenfield.com and do not assume we have received or are acting upon your filing instructions unless you receive written confirmation from us.
If you would like to discuss becoming a client, please contact one of our attorneys to arrange for a meeting or telephone conference.
There, that wasn’t so bad, was it? Thank you for your interest in Wolf Greenfield.
Andrew Mathis enjoys collaborating with clients to assist in developing and executing patent strategies that meet their needs. Andrew works in a wide variety of life sciences areas including enzyme/RNA engineering, next-generation sequencing, bioinformatics, machine learning/artificial intelligence, gene editing, vaccine design, immune therapy, cell therapy, antibodies, and molecular biology.
Andrew works with clients throughout the life sciences sector including academic institutions, research hospitals, start-ups, mid-sized biotech companies, and large pharmaceutical companies. He assists the firm in advising on a wide variety of IP issues including patent portfolio strategy, patent prosecution, patentability, freedom to operate, due diligence, licensing agreements, and trade secrets.
As part of his doctoral research, Andrew worked in the wet lab and the dry lab to develop a high-throughput assay for gradated knockdown of gene expression using CRISPR interference, next-generation sequencing, and bioinformatics analysis.
Experience
Drafted patent applications related to technologies including CAR-T cell therapies, protein biologics, and DNA sequencing data analysis.
Prosecuted patent applications related to DNA sequencing data analysis, CAR-T cell therapies, protein biologics, nanoparticle therapies, genetically engineered crops, and antisense oligonucleotides.
Assisted in patent counseling including freedom to operate, patentability, non-infringement, and validity analysis.
Mathis, A.D.; Otto, R.M.; Reynolds K.A., A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth. Nucleic Acids Research 49.1 (2021): e6-e6.
Schober, A. F.; Mathis, A. D.; Ingle, C.; Park, J. O.; Chen, L.; Rabinowitz, J. D.; Junier, I.; Rivoire, O.; Reynolds, K. A., A two-enzyme adaptive unit within bacterial folate metabolism., Cell Reports 2019, 27 (11), 3359-3370. E7.
Mathis, A. D.*; Naylor, B. C.*; Carson, R. H.; Evans, E.; Harwell, J.; Knecht, J.; Hexem, E.; Peelor, F. F.; Miller, B. F.; Hamilton, K. L., Transtrum M. K., Bikman, B. T., Price, J.C., Mechanisms of in vivo ribosome maintenance change in response to nutrient signals. Molecular & Cellular Proteomics 2017, 16 (2), 243-254. *These authors contributed equally
Plimpton, R. L.; Cuellar, J.; Lai, C. W. J.; Aoba, T.; Makaju, A.; Franklin, S.; Mathis, A. D.; Prince, J. T.; Carrascosa, J. L.; Valpuesta, J. M.; Willardson, B. M., Structures of the G beta-CCT and PhLP1-G beta-CCT complexes reveal a mechanism for G-protein beta-subunit folding and G beta gamma dimer assembly. Proceedings of the National Academy of Sciences USA 2015, 112(8), 2413-2418.
DeMille, D.; Badal, B. D.; Evans, J. B.; Mathis, A. D.; Anderson, J. F.; Grose, J. H., PAS kinaseis activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1. Molecular Biology of the Cell 2015, 26 (3), 569-582.
Weerasekara, V. K.; Panek, D. J.; Broadbent, D. G.; Mortenson, J. B.; Mathis, A. D.; Logan, G. N.; Prince, J. T.; Thomson, D. M.; Thompson, J. W.; Andersen, J. L., Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1-and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. Molecular and Cellular Biology 2014, 34 (24), 4379-4388.
Grose, J. H.; Belnap, D. M.; Jensen, J. D.; Mathis, A. D.; Prince, J. T.; Merrill, B. D.; Burnett, S. H.; Breakwell, D. P., The genomes, proteomes, and structures of three novel phages that infect the Bacillus cereus group and carry putative virulence factors. Journal of Virology 2014, 88 (20), 11846-11860.
DeMille, D.; Bikman, B. T.; Mathis, A. D.; Prince, J. T.; Mackay, J. T.; Sowa, S. W.; Hall, T. D.; Grose, J. H., A comprehensive protein–protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1. Molecular Biology of the Cell 2014, 25 (14), 2199-2215.
Smith, R.; Mathis, A. D.; Ventura, D.; Prince, J. T., Proteomics, lipidomics, metabolomics: a mass spectrometry tutorial from a computer scientist’s point of view. BMC Bioinformatics 2014,15 (7), 1.
