Overview
Cyrus Jin assists the Biotechnology Practice in matters related to patent prosecution. Cyrus has deep scientific experience in areas including targeted protein degradation, protein enzymology and biochemistry, structural biology, proteomics, and immunology.
Cyrus’s research has focused on investigating the structural and biochemical underpinnings of targeted protein degradation as a therapeutic modality. As a graduate student and postdoctoral fellow at Harvard Medical School/Dana-Farber Cancer Institute in the laboratory of Dr. Eric Fischer, he utilized a combination of biochemistry, structural biology, and various omics-based technologies to characterize native and ligand-bound E3 ubiquitin ligases.
Prior to his doctoral studies, Cyrus conducted undergraduate research at UCLA investigating the biochemical and physiological roles of protein arginine methyltransferases, and completed a summer internship in the Immunology Department at Gilead Sciences.
Cyrus also has previous patent prosecution assistance experience, having interned as a Scientific Analyst at a biotechnology-focused law firm, where he assisted with patent application preparation, office action responses, and IP due diligence.
Recognition
- Wasserman Grant, Undergraduate Research Scholarship Program (2016-2017)
- Zymo Summer Research Fellowship (2016)
- UCLA Regents Scholarship (2013-2017)
- Byun, W. S., Zhuang, Z., Hnatiuk, A. P., Jin, C.Y., Jiang, Z., Baek, K., Chao, E., Donovan, K. A., Fischer, E. S., Mercola, M., Gray, N. S. Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes. Journal of the American Chemical Society. 147, 35481–35492 (2025).
- Knoll, N., Masser, S., Bordas, B., Ebright, R. Y., Li, G., Kesar, D., Destefanis, E., Kania, N., Rodriguez, D. J., Jen, J., Zagar, S. E., Mensah, C., Chen, Z., Moffitt, S. J., Enakireru, E. M., He, Y., Feng, B., Chokshi, M. K., Jin, C. Y., Raghavan, S., Sellers, W. R., Mulvaney, K. M. CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer. Cancer Research. 85, 3518–3539 (2025).
- Warner, K., Hunkeler, M., Baek, K., Schmoker, A., Roy Burman, S. S., Overwijn, D., Jin, C.Y., Donovan, K. A., Fischer, E. S. Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1. Cell Reports. 44, 115688 (2025).
- Jin, C. Y., Hunkeler, M., Mulvaney, K. M., Sellers, W. R., Fischer, E. S. Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5. Journal of Biological Chemistry. 301, 108165 (2025).
- Hassan, M. M., Li, Y.-D., Ma, M. W., Teng, M., Byun, W. S., Puvar, K., Lumpkin, R. J., Sandoval, B., Rutter, J. C., Jin, C. Y., Wang, M. Y., Xu, S., Schmoker, A. M., Cheong, H., Groendyke, B. J., Qi, J., Fischer, E. S., Ebert, B. L., Gray, N. S. Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues. European Journal of Medicinal Chemistry. 279, 116904 (2024).
- Jin, C.Y., Kostic, M. F-boxing substrates away. Nature Chemical Biology. 20, 1550–1552 (2024).
- Li, Y.-D., Ma, M. W., Hassan, M. M., Hunkeler, M., Teng, M., Puvar, K., Rutter, J. C., Lumpkin, R. J., Sandoval, B., Jin, C. Y., Schmoker, A. M., Ficarro, S. B., Cheong, H., Metivier, R. J., Wang, M. Y., Xu, S., Byun, W. S., Groendyke, B. J., You, I., Sigua, L. H., Tavares, I., Zou, C., Tsai, J. M., Park, P. M. C., Yoon, H., Majewski, F. C., Sperling, H. T., Marto, J. A., Qi, J., Nowak, R. P., Donovan, K. A., Słabicki, M., Gray, N. S., Fischer, E. S., Ebert, B. L. Template-assisted covalent modification underlies activity of covalent molecular glues. Nature Chemical Biology. 20, 1640–1649 (2024).
- Kwon, M. C., Thuring, J. W., Querolle, O., Dai, X., Verhulst, T., Pande, V., Marien, A., Goffin, D., Wenge, D. V., Yue, H., Cutler, J. A., Jin, C.Y., Perner, F., Hogeling, S. M., Shaffer, P. L., Jacobs, F., Vinken, P., Cai, W., Keersmaekers, V., Eyassu, F., Bhogal, B., Verstraeten, K., El Ashkar, S., Perry, J. A., Jayaguru, P., Barreyro, L., Kuchnio, A., Darville, N., Krosky, D., Urbanietz, G., Verbist, B., Edwards, J. P., Cowley, G. S., Kirkpatrick, R., Steele, R., Ferrante, L., Guttke, C., Daskalakis, N., Pietsch, E. C., Wilson, D. M., Attar, R., Elsayed, Y., Fischer, E. S., Schuringa, J. J., Armstrong, S. A., Packman, K., Philippar, U. Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias. Blood. 144, 1206–1220 (2024).
- Monda, J. K., Ge, X., Hunkeler, M., Donovan, K. A., Ma, M. W., Jin, C. Y., Leonard, M., Fischer, E. S., Bennett, E. J. HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways. Cell Reports. 42, 112496 (2023).
- Hunkeler, M., Jin, C. Y., Fischer, E. S. Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science. 379, 1105–1111 (2023).
- Miller, P. G., Sathappa, M., Moroco, J. A., Jiang, W., Qian, Y., Iqbal, S., Guo, Q., Giacomelli, A. O., Shaw, S., Vernier, C., Bajrami, B., Yang, X., Raffier, C., Sperling, A. S., Gibson, C. J., Kahn, J., Jin, C.Y., Ranaghan, M., Caliman, A., Brousseau, M., Fischer, E. S., Lintner, R., Piccioni, F., Campbell, A. J., Root, D. E., Garvie, C. W., Ebert, B. L. Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state. Nature Communications. 13, 3778 (2022).
- Hunkeler, M., Jin, C. Y., Ma, M. W., Monda, J. K., Overwijn, D., Bennett, E. J., Fischer, E. S. Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Molecular Cell. 81, 3468–3480 (2021).
- Jain, K., Jin, C. Y., Clarke, S. G. Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases. Proceedings of the National Academy of Sciences of the United States of America. 114, 10101–10106 (2017).
