William Czaplyski

William Czaplyski, PhD

(he/him/his)
Associate | Pharmaceutical
617.646.8494 William.Czaplyski@WolfGreenfield.com LinkedIn Profile

Education

  • College of William & Mary, BS, Chemistry, summa cum laude
  • College of William & Mary, MS, Chemistry
  • University of North Carolina at Chapel Hill, PhD, Organic Chemistry
  • Harvard Law School, JD, cum laude

 

Key Technologies

  • Small Molecule Therapeutics
  • Medical Devices
  • Pharmaceutical Formulations
  • Selective Biomolecule Degradation
  • Biomolecule Conjugates

Practice Groups

Admitted to Practice

  • Massachusetts 
  • US Patent and Trademark Office

Location

  • Boston

Overview

Will Czaplyski focuses on patent prosecution and counseling in the pharmaceutical space. He has extensive experience in organic chemistry, including reaction methodology development, late-stage diversification of natural products, polymer chemistry, and small-molecule probes.

Will prepares and prosecutes US and foreign patent applications for a variety of technologies in the pharmaceutical and biotechnology spaces. He regularly conducts invalidity, non-infringement, patentability, and freedom-to-operate analyses and advises clients. In addition, he has experience assisting in transactional matters, including preparation of licensing and R&D collaboration agreements. 

Prior to joining Wolf Greenfield, Will obtained his JD from Harvard Law School and his PhD in organic chemistry from the University of North Carolina at Chapel Hill. His graduate research focused on radical-mediated aliphatic C–H functionalization of small molecules and polymers using a novel N-xanthylamide reagent. He also developed a strategy for aliphatic C–H functionalization using photoredox catalysis.

Will received his BS and MS degrees in chemistry at the College of William & Mary, where he studied novel pH-responsive fluorescent rhodamine dyes.

Most recently, Will spent two summers as summer associate at Wolf Greenfield.


Experience

  • Prepared and prosecuted US and foreign patent applications for a variety of technologies in the pharmaceutical and biotechnology spaces
  • Conducted invalidity, non-infringement, patentability, and freedom-to-operate analyses and advised clients
  • Assisted in transactional matters, including preparation of licensing and R&D collaboration agreements

Activities

  • Boston Patent Law Association

Recognition

  • University of North Carolina at Chapel Hill, Graduate School Travel Grant
  • University of North Carolina at Chapel Hill, Ernest L. Eliel Graduate Fellowship
  • University of North Carolina at Chapel Hill, National Science Foundation Graduate Research Fellowship Honorable Mention
  • College of William & Mary, Alfred R. Armstrong Outstanding Teaching Assistant Award
  • College of William & Mary, Phi Beta Kappa
  • College of William & Mary, S. Laurie Sanderson Award for Excellence in Undergraduate Mentoring in the Natural and Computational Sciences
  • College of William & Mary, Alumni Award for Excellence in Undergraduate Research
  • College of William & Mary, Summer Research Fellowship, Undergraduate Science Education and Research Program Sponsored by the Howard Hughes Medical Institute

Publications

Articles

Scientific Publications

  • Margrey, K. A.†; Czaplyski, W. L.†; Nicewicz, D. A.; Alexanian, E. J. “Modular Aliphatic C–H Functionalization Enabled by Organic Photoredox Catalysis.” Journal of the American Chemical Society, 2018, 140, 4213. †Co-first authors.
  • Williamson, J. B.†; Czaplyski, W. L.†; Alexanian, E. J.; Leibfarth, F. A. “Regioselective C–H Xanthylation as a Platform for Polyolefin Functionalization.” Angewandte Chemie International Edition, 2018, 57, 6261. †Co-first authors.
  • Stratton, S. G.; Taumoefolau, G. H.; Purnell, G. E.; Rasooly, M.; Czaplyski, W. L.; Harbron, E. J. “Tuning the pKa of Fluorescent Rhodamine pH Probes via Substituent Effects.” Chemistry: A European Journal, 2017, 23, 14064.
  • Jenkins, E. N.; † Czaplyski, W. L.; † Alexanian, E. J. “A General Approach to Quaternary Center Construction from Couplings of Unactivated Alkenes and Acyl Xanthates.” Organic Letters, 2017, 19, 2350. †Co-first authors.
  • Czaplyski, W. L.; Na, C. G.; Alexanian, E. J. “C–H Xanthylation: A Synthetic Platform for Alkane Functionalization.” Journal of the American Chemical Society, 2016, 138, 13854. Featured in the American Chemical Society Select Virtual Issue “Radicals in Action.”
  • Czaplyski, W. L.; Purnell, G. E.; Roberts, C. A.; Allred, R. M.; Harbron, E. J. “Substituent Effects on the Turn-On Kinetics of Rhodamine-Based Fluorescent pH Probes.” Organic & Biomolecular Chemistry, 2014, 12, 526.

Events