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Pardon the interruption, but we are lawyers after all, so we need to make sure you understand that sending an email does not establish an attorney-client relationship. Also, you need to know the information in your email will not be considered privileged or confidential unless, of course, we already represent you or have agreed to receive limited confidential material from you as a prospective client.
If you are a client, do not send time-sensitive patent filing instructions just to this email recipient. Also send to filinginstructions@wolfgreenfield.com and do not assume we have received or are acting upon your filing instructions unless you receive written confirmation from us.
If you would like to discuss becoming a client, please contact one of our attorneys to arrange for a meeting or telephone conference.
There, that wasn’t so bad, was it? Thank you for your interest in Wolf Greenfield.
Andrew Mathis assists the firm in biotechnology patent drafting, prosecution, and counseling. He works with clients in many technology areas, including cell therapy, protein biologics, gene editing, nanoparticles, antisense oligonucleotides, DNA sequencing, and bioinformatics. He has extensive knowledge in the areas of CRISPR interference, continuous culture, Illumina DNA sequencing, systems biology, molecular biology, and proteomics mass spectrometry. Andrew also has significant experience in computational biology and bioinformatics.
Prior to joining Wolf Greenfield, Andrew was a graduate student in Kimberly A. Reynolds’ laboratory at the University of Texas Southwestern Medical Center. His research focused on developing an assay for high-throughput, gradated knockdown of gene expression using CRISPR interference and next-generation sequencing. In addition to his lab work, Andrew was a volunteer reviewer for the Journal of Emerging Investigators.
Experience
Drafted patent applications related to technologies including CAR-T cell therapies, protein biologics, and DNA sequencing data analysis.
Prosecuted patent applications related to DNA sequencing data analysis, CAR-T cell therapies, protein biologics, nanoparticle therapies, genetically engineered crops, and antisense oligonucleotides.
Assisted in patent counseling including freedom to operate, patentability, non-infringement, and validity analysis.
Mathis, A.D.; Otto, R.M.; Reynolds K.A., A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth. Nucleic Acids Research 49.1 (2021): e6-e6.
Schober, A. F.; Mathis, A. D.; Ingle, C.; Park, J. O.; Chen, L.; Rabinowitz, J. D.; Junier, I.; Rivoire, O.; Reynolds, K. A., A two-enzyme adaptive unit within bacterial folate metabolism., Cell Reports 2019, 27 (11), 3359-3370. E7.
Mathis, A. D.*; Naylor, B. C.*; Carson, R. H.; Evans, E.; Harwell, J.; Knecht, J.; Hexem, E.; Peelor, F. F.; Miller, B. F.; Hamilton, K. L., Transtrum M. K., Bikman, B. T., Price, J.C., Mechanisms of in vivo ribosome maintenance change in response to nutrient signals. Molecular & Cellular Proteomics 2017, 16 (2), 243-254. *These authors contributed equally
Plimpton, R. L.; Cuellar, J.; Lai, C. W. J.; Aoba, T.; Makaju, A.; Franklin, S.; Mathis, A. D.; Prince, J. T.; Carrascosa, J. L.; Valpuesta, J. M.; Willardson, B. M., Structures of the G beta-CCT and PhLP1-G beta-CCT complexes reveal a mechanism for G-protein beta-subunit folding and G beta gamma dimer assembly. Proceedings of the National Academy of Sciences USA 2015, 112(8), 2413-2418.
DeMille, D.; Badal, B. D.; Evans, J. B.; Mathis, A. D.; Anderson, J. F.; Grose, J. H., PAS kinaseis activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1. Molecular Biology of the Cell 2015, 26 (3), 569-582.
Weerasekara, V. K.; Panek, D. J.; Broadbent, D. G.; Mortenson, J. B.; Mathis, A. D.; Logan, G. N.; Prince, J. T.; Thomson, D. M.; Thompson, J. W.; Andersen, J. L., Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1-and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. Molecular and Cellular Biology 2014, 34 (24), 4379-4388.
Grose, J. H.; Belnap, D. M.; Jensen, J. D.; Mathis, A. D.; Prince, J. T.; Merrill, B. D.; Burnett, S. H.; Breakwell, D. P., The genomes, proteomes, and structures of three novel phages that infect the Bacillus cereus group and carry putative virulence factors. Journal of Virology 2014, 88 (20), 11846-11860.
DeMille, D.; Bikman, B. T.; Mathis, A. D.; Prince, J. T.; Mackay, J. T.; Sowa, S. W.; Hall, T. D.; Grose, J. H., A comprehensive protein–protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1. Molecular Biology of the Cell 2014, 25 (14), 2199-2215.
Smith, R.; Mathis, A. D.; Ventura, D.; Prince, J. T., Proteomics, lipidomics, metabolomics: a mass spectrometry tutorial from a computer scientist’s point of view. BMC Bioinformatics 2014,15 (7), 1.
