Scientific Publications
Lamb GD, El-Hayek R, Ikemoto N, Stephenson DG. (2000) Effects of dihydropyridine receptor II-III loop peptides on Ca(2+) release in skinned skeletal muscle fibers. Am J Physiol Cell Physiol. 279(4):C891-905.
Yamamoto T, El-Hayek R, Ikemoto N. (2000) Postulated role of interdomain interaction within the ryanodine receptor in Ca(2+) channel regulation. J Biol Chem. 21;275(16):11618-25.
El-Hayek R, Saiki Y, Yamamoto T, Ikemoto N. A postulated role of the near amino-terminal domain of the ryanodine receptor in the regulation of the sarcoplasmic reticulum Ca(2+) channel. J Biol Chem. 19;274(47):33341-7.
Saiki Y, El-Hayek R, Ikemoto N. (1999) Involvement of the Glu724-Pro760 region of the dihydropyridine receptor II-III loop in skeletal muscle-type excitation-contraction coupling. J Biol Chem. 19;274(12):7825-32.
Ikemoto N, El-Hayek R. (1998) Signal transmission and transduction in excitation-contraction coupling. Adv Exp Med Biol. 453:199-207.
El-Hayek R, Ikemoto N. (1998) Identification of the minimum essential region in the II-III loop of the dihydropyridine receptor alpha 1 subunit required for activation of skeletal muscle-type excitation-contraction coupling. Biochemistry. 12;37(19):7015-20.
Ikemoto N, El-Hayek R. (1996) Reciprocal control of the conformational state of the sarcoplasmic reticulum calcium channel protein by polarization and depolarization in the transverse tubule. FEBS Lett. 7;394(3):330-4.
El-Hayek R, Lokuta AJ, Arévalo C, Valdivia HH. (1995) Peptide probe of ryanodine receptor function. Imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms. J Biol Chem. 1;270(48):28696-704.
Yano M, El-Hayek R, Ikemoto N. (1995) Effects of perchlorate on depolarization-induced conformational changes in the junctional foot protein and Ca2+ release from sarcoplasmic reticulum. Biochemistry. 3;34(39):12584-9.
El-Hayek R, Antoniu B, Wang J, Hamilton SL, Ikemoto N. (1995) Identification of calcium releasetriggering and blocking regions of the II-III loop of the skeletal muscle dihydropyridine receptor. J Biol Chem. 22;270(38):22116-8.
Yano M, El-Hayek R, Ikemoto N. (1995) Role of calcium feedback in excitation-contraction coupling in isolated triads. J Biol Chem. 25;270(34):19936-42.
Kerouz N, El-Hayek R, Langhough R, MacDonald MJ. (1995) Insulin doses in children using conventional therapy for insulin dependent diabetes. Diabetes Res Clin Pract. 29(2):113-20.
El-Hayek R, Yano M, Ikemoto N. (1995) A conformational change in the junctional foot protein is involved in the regulation of Ca2+ release from sarcoplasmic reticulum. Studies on polylysineinduced Ca2+ release. J Biol Chem. 30;270(26):15634-8.
Morrissette J, Krätzschmar J, Haendler B, El-Hayek R, Mochca-Morales J, Martin BM, Patel JR, Moss RL, Schleuning WD, Coronado R, et al. (1995) Primary structure and properties of helothermine, a peptide toxin that blocks ryanodine receptors. Biophys J. 68(6):2280-8.
El-Hayek R, Yano M, Antoniu B, Mickelson JR, Louis CF, Ikemoto N. (1995) Altered E-C coupling in triads isolated from malignant hyperthermia-susceptible porcine muscle. Am J Physiol. 268(6 Pt 1):C1381-6.
Ikemoto N, Yano M, El-Hayek R, Antoniu B, Morii M. (1994) Chemical depolarization-induced SR calcium release in triads isolated from rabbit skeletal muscle. Biochemistry. 13;33(36):10961-8.
Yano M, El-Hayek R, Antoniu B, Ikemoto N. (1994) Neomycin: a novel potent blocker of communication between T-tubule and sarcoplasmic reticulum. FEBS Lett. 12;351(3):349-52.
Connelly TJ, El-Hayek R, Sukhareva M, Coronado R. (1994) L-thyroxine activates the intracellular Ca2+ release channel of skeletal muscle sarcoplasmic reticulum. Biochem Mol Biol Int. 32(3):441-8.
MacDonald MJ, Kerouz N, El-Hayek R, Langhough R. (1993) Early referral of children with IDDM to a specialized program correlates with better long-term metabolic control. Diabetes Care. 16(9):1310-1.
El-Hayek R, Valdivia C, Valdivia HH, Hogan K, Coronado R. (1993) Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophys J. 65(2):779-89.
El-Hayek R, Parness J, Valdivia HH, Coronado R, Hogan K. (1992) Dantrolene and azumolene inhibit [3H]PN200-110 binding to porcine skeletal muscle dihydropyridine receptors. Biochem Biophys Res Commun. 16;187(2):894-900.
Allen DB, Fogo A, El-Hayek R, Langhough R, Friedman AL. (1992) Effects of prolonged growth hormone administration in rats with chronic renal insufficiency. Pediatr Res. 31(4 Pt 1):406-10.
Valdivia HH, Fuentes O, El-Hayek R, Morrissette J, Coronado R. (1991) Activation of the ryanodine receptor Ca2+ release channel of sarcoplasmic reticulum by a novel scorpion venom. J Biol Chem. 15;266(29):19135-8.