David Cauble counsels clients on all aspects of filing strategy, portfolio development and IP risk management in relation to chemical and pharmaceutical technologies. He has comprehensive experience in patent application drafting, prosecution and appeals, as well as freedom to operate and patentability analyses, and opinion drafting.

David has extensive knowledge in the areas of complex organic synthesis, medicinal chemistry and drug development, and was a Senior Scientist at Schering-Plough Research Institute, where his research focus was the synthesis of small-molecule kinase inhibitors. David earned his PhD from the University of Texas at Austin, studying under Michael J. Krische, and was a postdoctoral fellow at Stanford University in the labs of Barry M. Trost. Prior to graduate school, David worked for a startup company in North Carolina, where he developed fluorocarbon and siloxane polymers for use in liquid CO2-based applications.

Prior to joining Wolf Greenfield, David practiced at Lathrop & Gage in Boston.
  • Managed international patent portfolios covering several clinical candidate compounds
  • Drafted and prosecuted patent applications for pharmaceutical companies, universities, research institutes and hospitals in areas of small molecule and oligonucleotide compositions, synthesis methods, therapeutic methods and screening methodologies
  • Prepared patent landscapes and competitive intelligence reports in connection with industrial drug discovery programs
  • Prepared validity opinions in connection with licensing and investment transactions
  • American Chemical Society
  • Boston Patent Law Association       
                         

David was named to the 2017 list of Massachusetts Rising Stars by Super Lawyers.

Blogs

November 30, 2017

Taking the Lead – Small Molecule Nonobviousness



Scientific Publications

Yang, J.; Cauble, D. F.; Berro, A. J.; Bauld, N. L.; Krische, M. J. “A Mechanistic Dichotomy in the Reaction of Gilman Reagents with Conjugated Enones: Partitioning of Electron Transfer and Conjugate Addition Manifolds,” J. Org. Chem. 2004, 69, 7979.

Agapiou, K.; Cauble, D. F.; Krische, M. J. “Copper Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters and Nitriles as Terminal Electrophiles,” J. Am. Chem. Soc. 2004, 126, 4528.

Cauble, D. F.; Gipson, J. D.; Krische, M. J. “Diastereo- and Enantioselective Catalytic Carbometallative Aldol Cycloreduction: Tandem Conjugate Addition- Aldol Cyclization,” J. Am. Chem. Soc. 2003, 125, 1110.

Cauble, D. F.; Lynch, V.; Krische, M. J. “Studies on the Enantioselective Catalysis of Photochemically Promoted Transformations: “Sensitizing Receptors” as Chiral Catalysts,” J. Org. Chem. 2003, 68, 15.

Huddleston, R. R.; Cauble, D. F.; Krische, M. J. “Borane-Mediated Aldol Cycloreduction of Mono-Enone Mono-Ketones: Diastereoselective Formation of Quaternary Centers,” J. Org. Chem. 2003, 68, 11.

Archer, E. A.; Cauble, D. F. Jr.; Lynch, V.; Krische, M. J. “Synthetic Duplex Oligomers: Optimizing Interstrand Affinity in a Synthetic Duplex Dimer through the use of a Noncovalent Constraint,” Tetrahedron 2002, 58, 721.

Cauble, D. F. Jr.; Krische, M. J. “The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes,” Chemtracts 2002, 15, 380.


David is the co-inventor of six US patents.    
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David Cauble counsels clients on all aspects of filing strategy, portfolio development and IP risk management in relation to chemical and pharmaceutical technologies. He has comprehensive experience in patent application drafting, prosecution and appeals, as well as freedom to operate and patentability analyses, and opinion drafting.

David has extensive knowledge in the areas of complex organic synthesis, medicinal chemistry and drug development, and was a Senior Scientist at Schering-Plough Research Institute, where his research focus was the synthesis of small-molecule kinase inhibitors. David earned his PhD from the University of Texas at Austin, studying under Michael J. Krische, and was a postdoctoral fellow at Stanford University in the labs of Barry M. Trost. Prior to graduate school, David worked for a startup company in North Carolina, where he developed fluorocarbon and siloxane polymers for use in liquid CO2-based applications.

Prior to joining Wolf Greenfield, David practiced at Lathrop & Gage in Boston.
  • Managed international patent portfolios covering several clinical candidate compounds
  • Drafted and prosecuted patent applications for pharmaceutical companies, universities, research institutes and hospitals in areas of small molecule and oligonucleotide compositions, synthesis methods, therapeutic methods and screening methodologies
  • Prepared patent landscapes and competitive intelligence reports in connection with industrial drug discovery programs
  • Prepared validity opinions in connection with licensing and investment transactions
  • American Chemical Society
  • Boston Patent Law Association       
                         

David was named to the 2017 list of Massachusetts Rising Stars by Super Lawyers.

Scientific Publications

Yang, J.; Cauble, D. F.; Berro, A. J.; Bauld, N. L.; Krische, M. J. “A Mechanistic Dichotomy in the Reaction of Gilman Reagents with Conjugated Enones: Partitioning of Electron Transfer and Conjugate Addition Manifolds,” J. Org. Chem. 2004, 69, 7979.

Agapiou, K.; Cauble, D. F.; Krische, M. J. “Copper Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters and Nitriles as Terminal Electrophiles,” J. Am. Chem. Soc. 2004, 126, 4528.

Cauble, D. F.; Gipson, J. D.; Krische, M. J. “Diastereo- and Enantioselective Catalytic Carbometallative Aldol Cycloreduction: Tandem Conjugate Addition- Aldol Cyclization,” J. Am. Chem. Soc. 2003, 125, 1110.

Cauble, D. F.; Lynch, V.; Krische, M. J. “Studies on the Enantioselective Catalysis of Photochemically Promoted Transformations: “Sensitizing Receptors” as Chiral Catalysts,” J. Org. Chem. 2003, 68, 15.

Huddleston, R. R.; Cauble, D. F.; Krische, M. J. “Borane-Mediated Aldol Cycloreduction of Mono-Enone Mono-Ketones: Diastereoselective Formation of Quaternary Centers,” J. Org. Chem. 2003, 68, 11.

Archer, E. A.; Cauble, D. F. Jr.; Lynch, V.; Krische, M. J. “Synthetic Duplex Oligomers: Optimizing Interstrand Affinity in a Synthetic Duplex Dimer through the use of a Noncovalent Constraint,” Tetrahedron 2002, 58, 721.

Cauble, D. F. Jr.; Krische, M. J. “The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes,” Chemtracts 2002, 15, 380.

Blogs

November 30, 2017

Taking the Lead – Small Molecule Nonobviousness


David is the co-inventor of six US patents.