• Managed international patent portfolios covering several clinical candidate compounds
• Drafted and prosecuted patent applications for pharmaceutical companies, universities, research institutes and hospitals in areas of small molecule and oligonucleotide compositions, synthesis methods, therapeutic methods and screening methodologies
• Prepared patent landscapes and competitive intelligence reports in connection with industrial drug discovery programs
• Prepared validity opinions in connection with licensing and investment transactions

• American Chemical Society
• Boston Patent Law Association       

• Repeatedly named to The Best Lawyers in America©
• Repeatedly named to the list of Massachusetts Rising Stars by Super Lawyers

Blogs

Scientific Publications

Yang, J.; Cauble, D. F.; Berro, A. J.; Bauld, N. L.; Krische, M. J. “A Mechanistic Dichotomy in the Reaction of Gilman Reagents with Conjugated Enones: Partitioning of Electron Transfer and Conjugate Addition Manifolds,” J. Org. Chem. 2004, 69, 7979.

Agapiou, K.; Cauble, D. F.; Krische, M. J. “Copper Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters and Nitriles as Terminal Electrophiles,” J. Am. Chem. Soc. 2004, 126, 4528.

Cauble, D. F.; Gipson, J. D.; Krische, M. J. “Diastereo- and Enantioselective Catalytic Carbometallative Aldol Cycloreduction: Tandem Conjugate Addition- Aldol Cyclization,” J. Am. Chem. Soc. 2003, 125, 1110.

Cauble, D. F.; Lynch, V.; Krische, M. J. “Studies on the Enantioselective Catalysis of Photochemically Promoted Transformations: “Sensitizing Receptors” as Chiral Catalysts,” J. Org. Chem. 2003, 68, 15.

Huddleston, R. R.; Cauble, D. F.; Krische, M. J. “Borane-Mediated Aldol Cycloreduction of Mono-Enone Mono-Ketones: Diastereoselective Formation of Quaternary Centers,” J. Org. Chem. 2003, 68, 11.

Archer, E. A.; Cauble, D. F. Jr.; Lynch, V.; Krische, M. J. “Synthetic Duplex Oligomers: Optimizing Interstrand Affinity in a Synthetic Duplex Dimer through the use of a Noncovalent Constraint,” Tetrahedron 2002, 58, 721.

Cauble, D. F. Jr.; Krische, M. J. “The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes,” Chemtracts 2002, 15, 380.

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