K. Guadalupe Cruz

K. Guadalupe Cruz, PhD

Technology Specialist | Biotechnology
617.646.8444 lupe.cruz@wolfgreenfield.com LinkedIn Profile


  • BS, Neuroscience & Cognitive Sciences, Neurobiology emphasis, The University of Arizona, cum laude
  • PhD, Neuroscience, Massachusetts Institute of Technology

Key Technologies

  • AAV Technology
  • Antibodies
  • Gene Editing Technologies
  • Neuroscience
  • Optogenetics
  • Sensory Systems
  • Transgenic Mouse Models
  • Viral Vectors

Practice Groups


  • Spanish

Admitted to Practice

  • Not yet admitted to practice


  • Boston


Lupe Cruz assists the firm in biotechnology patent prosecution. Lupe has extensive experience in neuroscience, neurobiology, and cognitive sciences.

Prior to joining Wolf Greenfield, Lupe earned her PhD in Neuroscience at the Massachusetts Institute of Technology in the Laboratory of Mriganka Sur. During her doctorate, Lupe utilized state-of-the-art viral techniques (including rabies and AAV technology combined with site-directed recombination [Cre-lox, Flp-FRT]), immunohistochemistry strategies, and high-density electrodes for neural recordings to characterize the structural and electrophysiological relationship of the prefrontal cortex and superior colliculus. Lupe also developed a high-yield psychophysics task for quantifying visual behaviors in mice, to which she applied in vivo cell/projection-specific optogenetics and multiphoton calcium imaging, allowing her to characterize the functional contributions of the prefrontal-collicular circuit to visual decision-making.

While in graduate school, Lupe also served as a mentor for undergraduate and graduate students and was involved in many diversity and inclusion initiatives at MIT.


  • Society for Neuroscience


  • Diversity, Equity, Inclusion & Justice Impact Award, Dept. of Brain & Cognitive Sciences – MIT (2022)
  • NEI Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (F31), National Institutes of Health (2020 - 2023)
  • Trainee Professional Development Award, Society for Neuroscience (2020)
  • Angus MacDonald Award for Excellence in Undergraduate Teaching, Dept. of Brain & Cognitive Sciences – MIT (2020)
  • Graduate Women of Excellence, Office of Graduate Education – MIT (2019


Scientific Publications

  • Cruz, K. Guadalupe, Yi Ning Leow, Nhat Minh Le, Elie Adam, Rafiq Huda, and Mriganka Sur. "Cortical-Subcortical Interactions in Goal-Directed Behavior." Physiological Reviews (2022).
  • Huda, Rafiq, Grayson O. Sipe, Vincent Breton-Provencher, K. Guadalupe Cruz, Gerald N. Pho, Elie Adam, Liadan M. Gunter, Austin Sullins, Ian R. Wickersham, and Mriganka Sur. "Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior." Nature Communications 11, no. 1 (2020): 1-17.