Dan Young works with clients across a broad range of technology areas to develop and implement IP strategies that are aligned with their business goals through portfolio management, patent prosecution, due diligence support, and third-party IP evaluations, focusing primarily in the areas of cell-based therapies, nucleic acid-based therapies, immuno-oncology approaches, antibodies, vaccines, gene therapies, genomics and bioinformatics, biomedical devices, marine and clean energy technologies. 

A recipient of a Novartis Presidential Post-Doctoral Fellowship, Dan did his post-doctoral research at the Novartis Institute for BioMedical Research and in the Mitchison Lab in the Department of Systems Biology at Harvard Medical School. During this time, he was involved in an image-based genome-wide RNAi screen, and developed computational approaches to profile small-molecule libraries using multidimensional cell-based assays for lead discovery and characterization. Dan’s doctoral work focused on understanding molecular mechanisms of tissue-specific gene regulation, and involved use of chromatin assays, gene profiling and novel imaging techniques to elucidate epigenetic mechanisms of tissue-specific transcriptional control during cell growth and differentiation. During his master’s studies, Dan investigated the poroelastic material properties of bone tissue.

Before entering graduate school, Dan worked for several years as a mechanical engineer in the Hydraulics Laboratory at FMGlobal Research and as a licensed engineering officer in the United States Merchant Marine. Dan served as an operating engineer aboard steam turbine and diesel powered vessels in the Great Lakes and Mediterranean Sea. With this background, Dan also helps clients having patent matters unique to the maritime industry.

Dan is co-inventor of a US patent related to microscopic image analysis technology, and has co-authored more than 35 scientific research and review articles, including in Nature, Nature Chemical Biology, Nature Reviews Genetics, Nature Reviews Drug Discovery, and Proceedings of the National Academy of Sciences. One of Dan’s articles was voted “Must Read” by the Faculty of 1000 Biology.


  • Assisted corporate biotech fund with IP due diligence analysis of startup biopharmaceutical company.
  • Conducted IP diligence in connection with a corporate transaction involving a immuno-oncology company having an antibody screening and development platform.
  • Prepared non-infringement opinions relating to antibody-based diagnostic assays for cancer detection.
  • Developed and implemented an IP strategy for a start-up biotherapeutics company for domestic and foreign patent protection, and provided due diligence support through multiple rounds of financing.
  • Advised a start-up molecular diagnostics company with developing and implementing an overall patent strategy to help position it for a venture financing. 
  • Prepared and filed a series of patent applications for a local university to capture innovations relating to a therapeutic vaccine technology, which became founding IP for a venture backed start-up company. 
  • Co-authored an Amicus Brief on behalf of the Boston Patent Law Association that was filed with the Supreme Court of the United States in connection with Association for Molecular Pathology v. Myriad Genetics, 569 U.S. 12-398 (2013).
  • Boston Patent Law Association - Vice-President; Member of the Board of Governors; Co-chair of the Biotechnology Committee; Past chair, Activities and Public Relations Committee
  • Pioneer Valley Life Sciences Institute - Business Advisory Board Member
  • The Bioscience Network - Member, Program Committee
  • Sigma Xi
  • Phi Delta Phi
  • Repeatedly named to the list of Massachusetts Rising Stars by Super Lawyers.

Articles

June 1, 2016

USPTO Provides Updates to Patent Subject Matter Eligibility Guidance

Blogs

July 20, 2016

Section 112 Challenges Alive and Well at the PTAB for Functional Antibody Claims



Scientific Publications

Waller PR, Young DW. (2015) Diagnostic patenting since Myriad: an update. MLO Med Lab Obs. 47(4):46.

Waller PR, Young DW. (2013) After the Myriad decision: do hurdles remain for diagnostics competition? MLO Med Lab Obs. 45(9):46.

van der Deen M, Akech J, Lapointe D, Gupta S, Young DW, Montecino MA, Galindo M, Lian JB, Stein JL, Stein GS, van Wijnen AJ. (2012) Genomic promoter occupancy of runtrelated transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. J Biol Chem. 10;287(7):4503-17.

Zaidi SK, Young DW, Montecino M, van Wijnen AJ, Stein JL, Lian JB, Stein GS. (2011) Bookmarking the genome: maintenance of epigenetic information. J Biol Chem. 27;286(21):18355-61.

Stein GS, Stein JL, van Wijnen AJ, Lian JB, Zaidi SK, Nickerson JA, Montecino MA, Young DW. (2011) An architectural genetic and epigenetic perspective. Integr Biol (Camb). 3(4):297-303.

Zaidi SK, Young DW, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2010) Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information. Mol Cell Biol. 30(20):4758-66.

Zaidi SK, Medina RF, Pockwinse SM, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. (2010) Subnuclear localization and intranuclear trafficking of transcription factors. Methods Mol Biol. 647:77-93.

Zaidi SK, Young DW, Montecino MA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. (2010) Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet. 11(8):583-9.

Stein GS, Stein JL, Van Wijnen AJ, Lian JB, Montecino M, Croce CM, Choi JY, Ali SA, Pande S, Hassan MQ, Zaidi SK, Young DW. (2010) Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer. Adv Enzyme Regul. 50(1):1607.

Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. (2009) Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov. 8(7):567-78.

Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. (2009) Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer. Ann N Y Acad Sci. 1155:4-14.

Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. (2009) Transcription-factor-mediated epigenetic control of cell fate and lineage commitment. Biochem Cell Biol. 87(1):1-6.

Bakshi R, Zaidi SK, Pande S, Hassan MQ, Young DW, Montecino M, Lian JB, van Wijnen AJ, Stein JL, Stein GS. (2008) The leukemogenic t(8;21) fusion protein AML1ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. J Cell Sci. 1;121(Pt 23):3981-90.

Teplyuk NM, Galindo M, Teplyuk VI, Pratap J, Young DW, Lapointe D, Javed A, Stein JL, Lian JB, Stein GS, van Wijnen AJ. (2008) Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 10;283(41):27585-97.

Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. (2008) Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer. J Cell Biochem. 15;104(6):2016-26.

Pockwinse SM, Zaidi SK, Medina RF, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. (2008) In situ nuclear organization of regulatory machinery. Methods Mol Biol. 455:239-59.

van der Deen M, Hassan MQ, Pratap J, Teplyuk NM, Young DW, Javed A, Zaidi SK, Lian JB, Montecino M, Stein JL, Stein GS, van Wijnen AJ. (2008) Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells. Methods Mol Biol. 455:165-76.

Ali SA, Zaidi SK, Dacwag CS, Salma N, Young DW, Shakoori AR, Montecino MA, Lian JB, van Wijnen AJ, Imbalzano AN, Stein GS, Stein JL. (2008) Phenotypic transcription factors epigenetically mediate cell growth control. Proc Natl Acad Sci USA. 105(18):6632-7.

Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. (2008) Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. 4(1):59-68.

Bender A, Young DW, Jenkins JL, Serrano M, Mikhailov D, Clemons PA, Davies JW. (2007) Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint. Comb Chem High Throughput Screen. 10(8):719-31.

Zaidi SK, Young DW, Javed A, Pratap J, Montecino M, van Wijnen A, Lian JB, Stein JL, Stein GS. (2007) Nuclear microenvironments in biological control and cancer. Nat Rev Cancer. 7(6):454-63.

Young DW, Hassan MQ, Yang XQ, Galindo M, Javed A, Zaidi SK, Furcinitti P, Lapointe D, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2007) Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc Natl Acad Sci USA. 27;104(9):3189-94.

Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2007) Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 25;445(7126):442-6.

Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. (2007) Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem. 15;100(6):1509-17.

Lian JB, Stein GS, Javed A, van Wijnen AJ, Stein JL, Montecino M, Hassan MQ, Gaur T, Lengner CJ, Young DW. (2006) Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord. 7(12):1-16.

Stein GS, Lian JB, Stein JL, van Wijnen AJ, Javed A, Montecino M, Zaidi SK, Young DW, Choi JY, Pratap J. (2005) Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Adv Enzyme Regul. 45:136-54.

Pockwinse SM, Rajgopal A, Young DW, Mujeeb KA, Nickerson J, Javed A, Redick S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Doxsey SJ. (2006) Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. J Cell Physiol. 206(2):354-62.

Saltman LH, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, Amcheslavsky A, van Wijnen AJ, Stein JL, Stein GS, Lian JB, BarShavit Z. (2005) Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1. J Cell Physiol. 204(3):871-80.

Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ. (2005) The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem. 27;280(21):20274-85.

Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, van Wijnen AJ, Lian JB, Stein GS. (2005) The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep. 6(2):128-33.

Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 1;94(4):720-30.

Young DW, Zaidi SK, Furcinitti PS, Javed A, van Wijnen AJ, Stein JL, Lian JB, Stein GS. (2004) Quantitative signature for architectural organization of regulatory factors using intranuclear informatics. J Cell Sci. 1;117(Pt 21):4889-96.

Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, Lian JB, van Wijnen AJ, Stein GS. (2004) Intranuclear trafficking: organization and assembly of regulatory machinery for combinatorial biological control. J Biol Chem. 15;279(42):43363-6.

Stein GS, Lian JB, van Wijnen AJ, Stein JL, Montecino M, Javed A, Zaidi SK, Young DW, Choi JY, Pockwinse SM. (2004) Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene. 24;23(24):4315-29.

Zaidi SK, Young DW, Pockwinse SM, Javed A, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2003) Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Proc Natl Acad Sci USA. 9;100(25):14852-7.

Balint E, Lapointe D, Drissi H, van der Meijden C, Young DW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. (2003) Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem. 15;89(2):401-26.


Expand All

Dan Young works with clients across a broad range of technology areas to develop and implement IP strategies that are aligned with their business goals through portfolio management, patent prosecution, due diligence support, and third-party IP evaluations, focusing primarily in the areas of cell-based therapies, nucleic acid-based therapies, immuno-oncology approaches, antibodies, vaccines, gene therapies, genomics and bioinformatics, biomedical devices, marine and clean energy technologies. 

A recipient of a Novartis Presidential Post-Doctoral Fellowship, Dan did his post-doctoral research at the Novartis Institute for BioMedical Research and in the Mitchison Lab in the Department of Systems Biology at Harvard Medical School. During this time, he was involved in an image-based genome-wide RNAi screen, and developed computational approaches to profile small-molecule libraries using multidimensional cell-based assays for lead discovery and characterization. Dan’s doctoral work focused on understanding molecular mechanisms of tissue-specific gene regulation, and involved use of chromatin assays, gene profiling and novel imaging techniques to elucidate epigenetic mechanisms of tissue-specific transcriptional control during cell growth and differentiation. During his master’s studies, Dan investigated the poroelastic material properties of bone tissue.

Before entering graduate school, Dan worked for several years as a mechanical engineer in the Hydraulics Laboratory at FMGlobal Research and as a licensed engineering officer in the United States Merchant Marine. Dan served as an operating engineer aboard steam turbine and diesel powered vessels in the Great Lakes and Mediterranean Sea. With this background, Dan also helps clients having patent matters unique to the maritime industry.

Dan is co-inventor of a US patent related to microscopic image analysis technology, and has co-authored more than 35 scientific research and review articles, including in Nature, Nature Chemical Biology, Nature Reviews Genetics, Nature Reviews Drug Discovery, and Proceedings of the National Academy of Sciences. One of Dan’s articles was voted “Must Read” by the Faculty of 1000 Biology.


  • Assisted corporate biotech fund with IP due diligence analysis of startup biopharmaceutical company.
  • Conducted IP diligence in connection with a corporate transaction involving a immuno-oncology company having an antibody screening and development platform.
  • Prepared non-infringement opinions relating to antibody-based diagnostic assays for cancer detection.
  • Developed and implemented an IP strategy for a start-up biotherapeutics company for domestic and foreign patent protection, and provided due diligence support through multiple rounds of financing.
  • Advised a start-up molecular diagnostics company with developing and implementing an overall patent strategy to help position it for a venture financing. 
  • Prepared and filed a series of patent applications for a local university to capture innovations relating to a therapeutic vaccine technology, which became founding IP for a venture backed start-up company. 
  • Co-authored an Amicus Brief on behalf of the Boston Patent Law Association that was filed with the Supreme Court of the United States in connection with Association for Molecular Pathology v. Myriad Genetics, 569 U.S. 12-398 (2013).
  • Boston Patent Law Association - Vice-President; Member of the Board of Governors; Co-chair of the Biotechnology Committee; Past chair, Activities and Public Relations Committee
  • Pioneer Valley Life Sciences Institute - Business Advisory Board Member
  • The Bioscience Network - Member, Program Committee
  • Sigma Xi
  • Phi Delta Phi
  • Repeatedly named to the list of Massachusetts Rising Stars by Super Lawyers.

Scientific Publications

Waller PR, Young DW. (2015) Diagnostic patenting since Myriad: an update. MLO Med Lab Obs. 47(4):46.

Waller PR, Young DW. (2013) After the Myriad decision: do hurdles remain for diagnostics competition? MLO Med Lab Obs. 45(9):46.

van der Deen M, Akech J, Lapointe D, Gupta S, Young DW, Montecino MA, Galindo M, Lian JB, Stein JL, Stein GS, van Wijnen AJ. (2012) Genomic promoter occupancy of runtrelated transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. J Biol Chem. 10;287(7):4503-17.

Zaidi SK, Young DW, Montecino M, van Wijnen AJ, Stein JL, Lian JB, Stein GS. (2011) Bookmarking the genome: maintenance of epigenetic information. J Biol Chem. 27;286(21):18355-61.

Stein GS, Stein JL, van Wijnen AJ, Lian JB, Zaidi SK, Nickerson JA, Montecino MA, Young DW. (2011) An architectural genetic and epigenetic perspective. Integr Biol (Camb). 3(4):297-303.

Zaidi SK, Young DW, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2010) Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information. Mol Cell Biol. 30(20):4758-66.

Zaidi SK, Medina RF, Pockwinse SM, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. (2010) Subnuclear localization and intranuclear trafficking of transcription factors. Methods Mol Biol. 647:77-93.

Zaidi SK, Young DW, Montecino MA, Lian JB, van Wijnen AJ, Stein JL, Stein GS. (2010) Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet. 11(8):583-9.

Stein GS, Stein JL, Van Wijnen AJ, Lian JB, Montecino M, Croce CM, Choi JY, Ali SA, Pande S, Hassan MQ, Zaidi SK, Young DW. (2010) Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer. Adv Enzyme Regul. 50(1):1607.

Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. (2009) Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov. 8(7):567-78.

Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. (2009) Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer. Ann N Y Acad Sci. 1155:4-14.

Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. (2009) Transcription-factor-mediated epigenetic control of cell fate and lineage commitment. Biochem Cell Biol. 87(1):1-6.

Bakshi R, Zaidi SK, Pande S, Hassan MQ, Young DW, Montecino M, Lian JB, van Wijnen AJ, Stein JL, Stein GS. (2008) The leukemogenic t(8;21) fusion protein AML1ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. J Cell Sci. 1;121(Pt 23):3981-90.

Teplyuk NM, Galindo M, Teplyuk VI, Pratap J, Young DW, Lapointe D, Javed A, Stein JL, Lian JB, Stein GS, van Wijnen AJ. (2008) Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 10;283(41):27585-97.

Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, Ali SA, Pande S, Hassan MQ. (2008) Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer. J Cell Biochem. 15;104(6):2016-26.

Pockwinse SM, Zaidi SK, Medina RF, Bakshi R, Kota KP, Ali SA, Young DW, Nickerson JA, Javed A, Montecino M, van Wijnen AJ, Lian JB, Stein JL, Stein GS. (2008) In situ nuclear organization of regulatory machinery. Methods Mol Biol. 455:239-59.

van der Deen M, Hassan MQ, Pratap J, Teplyuk NM, Young DW, Javed A, Zaidi SK, Lian JB, Montecino M, Stein JL, Stein GS, van Wijnen AJ. (2008) Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells. Methods Mol Biol. 455:165-76.

Ali SA, Zaidi SK, Dacwag CS, Salma N, Young DW, Shakoori AR, Montecino MA, Lian JB, van Wijnen AJ, Imbalzano AN, Stein GS, Stein JL. (2008) Phenotypic transcription factors epigenetically mediate cell growth control. Proc Natl Acad Sci USA. 105(18):6632-7.

Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. (2008) Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. 4(1):59-68.

Bender A, Young DW, Jenkins JL, Serrano M, Mikhailov D, Clemons PA, Davies JW. (2007) Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint. Comb Chem High Throughput Screen. 10(8):719-31.

Zaidi SK, Young DW, Javed A, Pratap J, Montecino M, van Wijnen A, Lian JB, Stein JL, Stein GS. (2007) Nuclear microenvironments in biological control and cancer. Nat Rev Cancer. 7(6):454-63.

Young DW, Hassan MQ, Yang XQ, Galindo M, Javed A, Zaidi SK, Furcinitti P, Lapointe D, Montecino M, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2007) Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc Natl Acad Sci USA. 27;104(9):3189-94.

Young DW, Hassan MQ, Pratap J, Galindo M, Zaidi SK, Lee SH, Yang X, Xie R, Javed A, Underwood JM, Furcinitti P, Imbalzano AN, Penman S, Nickerson JA, Montecino MA, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2007) Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 25;445(7126):442-6.

Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS. (2007) Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. J Cell Biochem. 15;100(6):1509-17.

Lian JB, Stein GS, Javed A, van Wijnen AJ, Stein JL, Montecino M, Hassan MQ, Gaur T, Lengner CJ, Young DW. (2006) Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord. 7(12):1-16.

Stein GS, Lian JB, Stein JL, van Wijnen AJ, Javed A, Montecino M, Zaidi SK, Young DW, Choi JY, Pratap J. (2005) Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer. Adv Enzyme Regul. 45:136-54.

Pockwinse SM, Rajgopal A, Young DW, Mujeeb KA, Nickerson J, Javed A, Redick S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Doxsey SJ. (2006) Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2. J Cell Physiol. 206(2):354-62.

Saltman LH, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, Amcheslavsky A, van Wijnen AJ, Stein JL, Stein GS, Lian JB, BarShavit Z. (2005) Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1. J Cell Physiol. 204(3):871-80.

Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ. (2005) The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem. 27;280(21):20274-85.

Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, van Wijnen AJ, Lian JB, Stein GS. (2005) The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep. 6(2):128-33.

Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 1;94(4):720-30.

Young DW, Zaidi SK, Furcinitti PS, Javed A, van Wijnen AJ, Stein JL, Lian JB, Stein GS. (2004) Quantitative signature for architectural organization of regulatory factors using intranuclear informatics. J Cell Sci. 1;117(Pt 21):4889-96.

Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, Lian JB, van Wijnen AJ, Stein GS. (2004) Intranuclear trafficking: organization and assembly of regulatory machinery for combinatorial biological control. J Biol Chem. 15;279(42):43363-6.

Stein GS, Lian JB, van Wijnen AJ, Stein JL, Montecino M, Javed A, Zaidi SK, Young DW, Choi JY, Pockwinse SM. (2004) Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene. 24;23(24):4315-29.

Zaidi SK, Young DW, Pockwinse SM, Javed A, Lian JB, Stein JL, van Wijnen AJ, Stein GS. (2003) Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Proc Natl Acad Sci USA. 9;100(25):14852-7.

Balint E, Lapointe D, Drissi H, van der Meijden C, Young DW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. (2003) Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem. 15;89(2):401-26.

Articles

June 1, 2016

USPTO Provides Updates to Patent Subject Matter Eligibility Guidance

Blogs

July 20, 2016

Section 112 Challenges Alive and Well at the PTAB for Functional Antibody Claims